- Check for connection issues if it’s a Bluetooth-powered keyboard and mouse.
- Motherboard settings can be reset by taking out the CMOS battery.
- USB Selective Suspend Setting makes it difficult for the mouse and keyboard to resume power when the laptop sleeps.
Basic Fixes
- Restart PC: A simple restart can refresh the system memory, clear temporary glitches, and reload device drivers, fixing issues caused by outdated or corrupted files. This is especially helpful if there’s a problem with your current Windows session.
- Run Bluetooth troubleshooter: This built-in utility scans for common connectivity issues with Bluetooth devices, such as incorrect settings or driver conflicts, and fixes them automatically. It’s a quick and easy way to resolve pairing problems. You can access it through Windows settings.
- Reconnect wired connection: Disconnect and reconnect the USB cable to ensure your wired mouse and keyboard are securely connected. If issues persist, try different USB ports, as this can help rule out port-specific problems.
- Try on another PC or Laptop. Test your mouse and keyboard on another computer to determine if the issue is with your devices or your original PC setup. This will help you identify whether the problem is hardware-related or software-related.
Method 1. Disable USB Selective Suspend Setting
In layman’s terms, the USB Selective Suspend settings suspend USB connections (or put them in a low-power state) to save power on battery devices (laptops). This can prevent you from using mouse and keyboard on your Windows PCs:
Step 1. Open the Control Panel by searching for it in the Windows Start menu.
Step 2. In the Control Panel, change the View by to Large icons and then open Power options .

Step 3. Now click on Change Plan Settings on your current power plan.

Step 4. After this, click Change Advanced Power settings. In the next window, scroll down to find and expand the USB Settings option.
Step 5. Now, you will see the USB Selective Suspend Settings . Expand it and disable it for both the On Battery and Plugged-in states.

Step 6. Click Apply and then Click OK to save the settings.
Method 2 Reset BIOS or UEFI
The BIOS or UEFI firmware settings are responsible for identifying and connecting to USB devices and other devices, which are crucial for your PC’s functioning during boot. If the BIOS or UEFI settings are misconfigured, you will encounter issues.
Step 1. To reset BIOS or UEFI settings, restart your PC and press the F8, F12, or ESC key repeatedly to enter the BIOS (the key to enter BIOS can be different for your device’s manufacturer)
Step 2. Once you are in the BIOS, press the F9 key to reset the BIOS. Click Yes on the prompt to finally reset the settings.

Please note that the BIOS interface is different for different motherboard and PC manufacturers, so the position of the respective settings can vary. However, in most cases, you should look for the Reset BIOS, Load Setup Defaults, or Load Defaults settings in the BIOS to reset it. Also, note that resetting BIOS will reset the boot sequence and all the other settings.
Method 3. Change Motherboard Battery
Sometimes, the issue might be as simple as a discharged motherboard battery. This battery powers the CMOS, which stores your BIOS settings. A low battery can cause many issues, including problems with the mouse and keyboard.
Step 1. Turn off your PC and unplug the power cord. This will ensure that no electricity flows through the system.
Step 2. Open your PC’s side panel. Depending on your case, you may need a screwdriver for this. Locate the motherboard battery. It’s a small, coin-shaped battery (usually a CR2032).
Step 3. Carefully remove the battery from its socket. You might need to pry it with your fingernail or a non-metallic tool gently.
Step 4. Wait for a couple of minutes. This allows the CMOS to discharge completely, clearing any potentially corrupted settings.
Step 5. Insert a new CR2032 battery (or reinsert the old one if you think it still has charge) into the socket, ensuring the positive (+) side faces up.
Step 6. Close the side panel of your PC, plug in the power cord, and start the computer.